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KMID : 1007520090180020475
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Food Science and Biotechnology
2009 Volume.18 No. 2 p.475 ~ p.480
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Effects of Aucubin Isolated from Eucommia ulmoides on UVB-induced Oxidative Stress in Human Keratinocytes HaCaT
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Ho Jin-Nyoung
Cho Hong-Yon
Lim Eun-Jeong
Kim Hye-Kyung
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Abstract
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Ultraviolet B (UVB) radiation provokes the generation of reactive oxygen species (ROS) in the cells and skin, whichinduce oxidative stress in the exposed cells, leading to photoaging and cancer. Using the human keratinocytes HaCaT cell line, weinvestigated the photoprotective effects of aucubin isolated from Eucommia ulmoides. Pretreatment with aucubin markedlysuppressed UVB-induced oxidative stress, which manifests as a decrease in intracellular lipid peroxidation, elevation of catalaseactivity, and reduced glutathione content. In addition, aucubin significantly reduced expression of matrix metalloproteinase-1(MMP-1) protein (54%) and mRNA. Taken together, these results suggest that aucubin may offer protection against UVB-induced oxidative stress and may be used as a potential agent in prevention of UVB-induced photoaging.
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KEYWORD
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photoaging, ultraviolet B (UVB), aucubin, oxidative stress, matrix metalloproteinase-1 (MMP-1)
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